000			02779cam a22003738i 4500
999			_c8616 _d8616
001			18927919
003			OSt
005			20200303145621.0
008			160104s2016 enk b 001 0 eng
010			_a 2015051480
020			_a9781107035416 (hardback)
035			_a(DNLM)101674577
040			_aDNLM/DLC _cDLC _erda
042			_apcc
050	0	0	_aRC521
060	1	0	_aWM 220
082	0	0	_a616.83 FIL _223
100	1		_aFilley, Christopher M., _d1951- , _eauthor.
245	1	0	_aWhite matter dementia / _cChristopher M. Filley.
263			_a1605
264		1	_aCambridge ; _aNew York : _bCambridge University Press, _c2016.
300			_ap. ; _ccm.
336			_atext _2rdacontent
337			_aunmediated _2rdamedia
338			_avolume _2rdacarrier
504			_aIncludes bibliographical references and index.
505	8		_aMachine generated contents note: Preface; 1. Brain-behavior relationships: a reconsideration; 2. The essential contributions of neuroimaging; 3. White matter neurobiology; 4. A neuroanatomic overview of dementia; 5. Expanding the concept of dementia; 6. White matter disorders; 7. White matter dementia; 8. Mild cognitive dysfunction: a precursor syndrome; 9. Diagnosis; 10. Prognosis; 11. Treatment; 12. White matter and cognition: research perspectives; 13. Therapeutic innovations; 14. Alzheimer's disease and white matter; 15. Chronic traumatic encephalopathy and white matter; 16. Beyond corticocentrism; Index.
520			_a"Breaking away from prevailing views of dementia that rely heavily on the role of the cerebral cortex, the new perspective put forth here highlights white matter-cognition relationships, presenting an expanded view of dementia and its neurobiological origins. Based on detailed patient observations, extensive clinical research and an exhaustive literature review, this book discusses the novel concept of white matter dementia, offering hope for better understanding and treatment of dementing illness. Covering topics such as white matter neurobiology, mild cognitive dysfunction and Alzheimer's disease, the author reconsiders brain-behavior relationships and expands the concept of dementia, discussing implications for diagnosis, treatment (medical, surgical, rehabilitative, and psychiatric) and therapeutic innovations aimed at prevention of white matter damage and restoration of myelin. This unique book is an absolute must-have for all medical specialists and consultants in neurology, neuropsychiatry, and neuropsychology involved with the growing challenge of dementia"--Provided by publisher.
650	1	2	_aDementia _xphysiopathology
650	1	2	_aWhite Matter _xphysiopathology
650	2	2	_aDementia _xdiagnosis
906			_a7 _bcbc _corignew _d1 _eecip _f20 _gy-gencatlg
942			_2ddc _cRFT