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008			180718s2018 gw |||| o |||| 0|eng
010			_a 2019743930
020			_a9783319925073
024	7		_a10.1007/978-3-319-92507-3 _2doi
035			_a(DE-He213)978-3-319-92507-3
040			_aDLC _beng _epn _erda _cDLC
072		7	_aMED057000 _2bisacsh
072		7	_aPSAN _2bicssc
072		7	_aPSAN _2thema
082	0	4	_a617.8 RAM R _223
245	0	0	_aInflammatory Mechanisms in Mediating Hearing Loss / _cedited by Vickram Ramkumar, Leonard P. Rybak.
250			_a1st ed. 2018.
264		1	_aCham : _bSpringer International Publishing : _bImprint: Springer, _c2018.
300			_aX, 231 pages 39 illustrations, 31 illustrations in color.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aPreface -- The Cochlea -- Oxidative Stress and Hearing Loss -- Corticotropin Releasing Factor Signaling in the Mammalian Cochlea: An Integrative Niche for Cochlear Homeostatic Balance Against Noise -- Cochlear vascular pathology and hearing loss -- Cochlear Inflammation Associated with Noise-Exposure -- Middle Ear Infection and Hearing Loss -- Inflammation potentiates cochlear uptake of ototoxins and drug-induced hearing loss -- The Contribution of Anti-Oxidant and Anti-Inflammatory Functions of Adenosine A1 Receptor In Mediating Otoprotection -- Anti-inflammatory therapies for sensorineural hearing loss -- Implementation and Outcomes of Clinical Trials in Immune-Mediated Hearing Loss and other Rare Diseases -- Index.
520			_aThe primary goal of this project is to describe our current understanding of the oxidant hypothesis of noise and drug-induced hearing loss and show how this process translates into cochlear inflammation. Basic cellular mechanisms underlying the contribution of oxidant stress to hearing loss will be explained and molecular pathways leading to inflammatory processes will be outlined. Several different aspects of the cochlear inflammatory process will be discussed in detail. These include the sources of inflammatory cells, chemokines, inflammatory cytokines and the roles of cochlear resident immune cells in mediating hearing loss. In addition, evidence for a robust cochlear-based steroid axis which is activated by cochlear stress and serves a protective system. The role of the strial vasculature networks which aid in maintenance of the blood-labyrinth barrier and control the entry of circulating immune cells into the cochlea will be described. Molecular pathways leading to activation of the local inflammatory process will be highlighted and otoprotective treatment options will be discussed. The relevance of certain clinically used anti-inflammatory interventions, such as trans-tympanic steroids and other drugs will also be discussed. Furthermore, we will examine recent patents focusing on the use of anti-inflammatory agents for the treatment of drug and noise-induced hearing loss. It is our hope that this book would provide a better understanding of the interaction of oxidative stress and inflammation in hearing loss. This book should provide basic information to scientists in the field of auditory research and to enlighten clinicians who treat patients with potentially ototoxic drugs.
588			_aDescription based on publisher-supplied MARC data.
650		0	_aNeurosciences.
650		0	_aOtorhinolaryngology.
650	1	4	_aNeurosciences. _0https://scigraph.springernature.com/ontologies/product-market-codes/B18006
650	2	4	_aOtorhinolaryngology. _0https://scigraph.springernature.com/ontologies/product-market-codes/H46007
700	1		_aRamkumar, Vickram. _eeditor.
700	1		_aRybak, Leonard P. _eeditor.
776	0	8	_iPrint version: _tInflammatory mechanisms in mediating hearing loss _z9783319925066 _w(DLC) 2018948194
776	0	8	_iPrinted edition: _z9783030064471
776	0	8	_iPrinted edition: _z9783319925066
776	0	8	_iPrinted edition: _z9783319925080
906			_a0 _bibc _corigres _du _encip _f20 _gy-gencatlg
942			_2ddc _cRFT