000			02541caa a2200301 4500
008			210629s9999 xx 000 0 und d
022			_a2051-2082
100			_aThakur, A
245		0	_a Tranexamic acid has no advantage in head and neck surgical procedures: a randomised, double-blind, controlled clinical trial
260			_c2019
270			_aDepartment of Biostatistics, All India Institute of Speech and Hearing, Mysore, India.
270			_aDepartment of Otolaryngology - Head and Neck Surgery, Indira Gandhi Medical College, Shimla, India.
270			_aDepartment of Pharmacology, Indira Gandhi Medical College, Shimla, India.
300			_a1024-1032
490			_vVolume 133 Issue 12
520			_aObjective: To assess the effect of tranexamic acid in head and neck surgical procedures.Methods: A prospective, double-blind and randomised, parallel group, placebo-controlled clinical trial was conducted. Ninety-two patients undergoing various head and neck surgical procedures were randomised. Subjects received seven infusions of coded drugs (tranexamic acid or normal saline) starting at the time of skin closure. Haematological, biochemical, blood loss and other parameters were observed by the staff, who were blinded to patients' group allocation (case or control).Results: Patients were analysed on the basis of type of surgery. Fifty patients who had undergone surgical procedures, including total thyroidectomy, total parotidectomy, and various neck dissections with or without primary tumour excision, were included in the first group. The second group comprised 41 patients who had undergone hemithyroidectomy, lobectomy or superficial parotidectomy. There was no statistical difference in blood parameters between both groups. There was a reduction in post-operative drain volume, but this was not significant.Conclusion: Although this prospective, randomised, placebo-controlled clinical trial found a reduction in post-operative drain volume in tranexamic acid groups, the difference was not statistically significant between the various head and neck surgical procedure groups.
653			_aControlled Clinical Trial; Head; Neck; Surgery; Tranexamic Acid.
700			_aAzad, R K
700			_aGupta, S
700			_aMinhas, R S
700			_aMohindroo, N K
700			_aSharma, D R
700			_aThakur, J S
700			_aVasanthalakshmi, M S
773			_aThe Journal of Laryngology and Otology
856			_uhttps://doi.org/10.1017/s0022215119002305
942			_cFJAS _yFJAS
999			_c18028 _d18028