000			02176caa a2200205 4500
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022			_a2169-5725
100			_aNiraj Kumar Singh
245		0	_aAssessment of otolith mediated neural reflexes through cervical and ocular vestibular evoked myogenic potentials in individuals with auditory neuropathy spectrum disorders
260			_bInforma UK Limited _c2016
300			_a77-90
490			_vVolume 14 Issue 2
520			_aAuditory neuropathy spectrum disorder (ANSD) is characterized by abnormal auditory neural function in the presence of normal cochlear function. Although the presence of vestibular dysfunction has been reported in ANSD through sporadic studies, cervical and ocular vestibular evoked myogenic potentials (cVEMP and oVEMP) were sparingly explored in the same individuals with ANSD. Thus, the present study aimed at investigating otolith modulated neural function in individuals with ANSD. A static group comparison research design was used. cVEMP and oVEMP were elicited by 500-Hz tone bursts from 31 individuals with ANSD and 31 age- and gender-matched healthy controls. Results showed that the response prevalence was less than 20% for both potentials. The present responses were characterized by significant prolongation of later peaks and inter-peak latency intervals and significantly reduced amplitudes compared to the controls (p < 0.001). Both potentials exhibited larger asymmetry ratios compared to the controls, but only cVEMP asymmetry ratio reached a statistically significant level. There was no association of cVEMP and oVEMP response prevalence with the presence of vestibular symptoms. Abnormal or absent responses in the majority of individuals suggest superior and inferior vestibular nerve dysfunction in ANSD. A detailed vestibular evaluation, in addition to the auditory system assessment, is strongly recommended in ANSD.
653			_acVEMP, oVEMP, ANSD, saccule, utricle
700			_aAnimesh Barman
700			_aSujeet Kumar Sinha
773			_aHearing, Balance and Communication
856			_uhttps://doi.org/10.3109/21695717.2016.1152047
942			_cFJAS _yFJAS
999			_c17790 _d17790