02779cam a22003738i 4500 8616 8616 18927919 OSt 20200303145621.0 160104s2016 enk b 001 0 eng 2015051480 9781107035416 (hardback) (DNLM)101674577 DNLM/DLC DLC rda pcc RC521 WM 220 616.83 FIL 23 Filley, Christopher M., 1951- , author. White matter dementia / Christopher M. Filley. 1605 Cambridge ; New York : Cambridge University Press, 2016. p. ; cm. text rdacontent unmediated rdamedia volume rdacarrier Includes bibliographical references and index. Machine generated contents note: Preface; 1. Brain-behavior relationships: a reconsideration; 2. The essential contributions of neuroimaging; 3. White matter neurobiology; 4. A neuroanatomic overview of dementia; 5. Expanding the concept of dementia; 6. White matter disorders; 7. White matter dementia; 8. Mild cognitive dysfunction: a precursor syndrome; 9. Diagnosis; 10. Prognosis; 11. Treatment; 12. White matter and cognition: research perspectives; 13. Therapeutic innovations; 14. Alzheimer's disease and white matter; 15. Chronic traumatic encephalopathy and white matter; 16. Beyond corticocentrism; Index. "Breaking away from prevailing views of dementia that rely heavily on the role of the cerebral cortex, the new perspective put forth here highlights white matter-cognition relationships, presenting an expanded view of dementia and its neurobiological origins. Based on detailed patient observations, extensive clinical research and an exhaustive literature review, this book discusses the novel concept of white matter dementia, offering hope for better understanding and treatment of dementing illness. Covering topics such as white matter neurobiology, mild cognitive dysfunction and Alzheimer's disease, the author reconsiders brain-behavior relationships and expands the concept of dementia, discussing implications for diagnosis, treatment (medical, surgical, rehabilitative, and psychiatric) and therapeutic innovations aimed at prevention of white matter damage and restoration of myelin. This unique book is an absolute must-have for all medical specialists and consultants in neurology, neuropsychiatry, and neuropsychology involved with the growing challenge of dementia"--Provided by publisher. Dementia physiopathology White Matter physiopathology Dementia diagnosis 7 cbc orignew 1 ecip 20 y-gencatlg ddc RFT 0 0 ddc 0 0 R-33/4 AIISH AIISH 2020-03-03 0 616.83 FIL 21375 2020-03-03 00:00:00 2020-03-03 RFT