02618cam a2200421 i 450000100090000000300040000900500170001300800410003001000170007101500190008801600200010701600180012702000350014502000320018002000060021203500240021804000540024204200080029605000210030406000150032506000110034007200130035108200160036424500670038026400310044726400110047830000570048933600260054633700280057233800270060050400410062750513670066865000330203565000250206865000410209365000360213470000260217018152645OSt20191105144747.0140515t20142014ja a     b    000 0 eng c  a  2014940851  aGBB4786082bnb7 a1016412262DNLM7 a0168025642Uk  a9784431548614 (acidfree paper)  a4431548610 (acidfree paper)  z   a(OCoLC)ocn876685409  aNLMbengcNLMerdadBTCTAdUKMGBdOHXdYDXCPdDLC  apcc00aRF260b.R44 201400a2014 K-04710aWV 250 7aRF2lcco  a617.882 ITO00aRegenerative medicine for the inner ear /cJuichi Ito, editor. 1aTokyo :bSpringer,c[2014] 4c©2014  axi, 321 pages :billustrations (some color) ;c25 cm  atextbtxt2rdacontent  aunmediatedbn2rdamedia  avolumebnc2rdacarrier  aIncludes bibliographical references.  aPart I Targets of Regenerative Medicine for the Inner Ear.- 1 Anatomy of the Inner Ear.- 2 Therapeutic Targets and Possible Strategies for Regenerative Medicine for the Inner Ear.- 3 Hair cell.- 4 Stereocilia.- 5 Cochlear Lateral Wall.- 6 Spiral Ganglion Cell and Auditory Neuron.- 7 Synaptic Contacts between Hair Cells and Primary Neurons.- 8 Otolith.- 9 Tectorial membrane.- Part II Development of the Inner Ear.- 10 Development and regeneration.- 11 Otic Induction.- 12 Cochlear Development.- 13 Vestibular Development.- Part III Cochlear Implants.- 14 Cochlear Implant: Past, Present and Future.- 15 Recent Progress in Cochlear Implant.- 16 Regenerative medicine in cochlear implantation.- 17 Artificial cochlear epithelium.- 18 Auditory Brainstem Implant.- Part IV Hair Cell Regeneration.- 19 Hair Cell Regeneration in the Avian.- 20 Self Repair.- 21 Transdifferentiation.- 22 Dedifferentiation-mediated Regeneration.- 23 Gene Therapy.- 24 Cell Therapy.- Part V Spiral Ganglion Neuron Regeneration.- 25 Clinical Background.- 26 SGN development.- 27 Gene Therapy for Regeneration and Preservation of Spinal Ganglion Neurons.- 28 Cell therapy.- 29 Afferent dendrite and axon.- Part VI Stem Cells.- 30 Inner ear stem cells.- 31 Pluripotent Stem Cells.- 32 Somatic Stem Cells.- Part VII Future Perspective.- 33 Regenerative Medicine for the Inner Ear - Summary12aLabyrinth Diseasesxsurgery.22aEar, Innerxsurgery.22aLabyrinth Diseasesxphysiopathology.22aRegenerative Medicinexmethods.1 aIto, Juichi,eeditor.