04951cam a2200325 i 4500999001700000001000900017003000400026005001700030008004100047010001700088020003100105040002300136042000800159082001400167100003200181245019500213264009500408300005800503336002600561337002800587338002700615504005100642505360500693650001404298650001704312906004504329942001304374952011304387952012504500  c19484d1948423193022OSt20240710123214.0230620s2022    enka     b    001 0 eng    a  2022438117  a9780323919128q(paperback)  aDLCbengerdacDLC  apcc  a617.8 EGG1 aEggermont, Jos J.,eauthor.10aTinnitus and hyperacusis :bfacts, theories, and clinical implications /cJos J. Eggermont, Department of Physiology, Pharmacoloy, and Psychology, University of Calgary, Calgary, AB, Canada. 1aLondon, United Kingdom ;aSan Diego, CA :bAcademic Press, an imprint of Elsevier,c[2022]  axix, 311 pages :billustrations (some color) ;c23 cm  atextbtxt2rdacontent  aunmediatedbn2rdamedia  avolumebnc2rdacarrier  aIncludes bibliographical references and index.  aCover image
Title page
Table of Contents
Copyright
Preface
Abbreviations in the main text
Chapter 1. Tinnitus, hyperacusis, and hearing loss
1.1. Introduction
1.2. Acquired hearing loss
1.3. Loudness recruitment
1.4. Noise-induced temporary threshold shifts
1.5. Noise exposure not causing PTS or TTS
1.6. Tinnitus pitch, loudness, and hearing loss
1.7. Summary
Chapter 2. Epidemiology, etiology, and genetics
2.1. Prevalence of tinnitus and hyperacusis
2.2. Etiology
2.3. Genetics
2.4. Summary
Chapter 3. Physiological markers of tinnitus and hyperacusis
3.1. Spontaneous neural activity. Noise or information carrier?
3.2. Spike-firing synchrony
3.3. Brain rhythms
3.4. Thalamocortical oscillations
3.5. Spike-LFP and EEG/MEG correlation and networks in human cortex
3.6. Auditory-evoked potentials
3.7. Summary
Chapter 4. Substrates of tinnitus and hyperacusis in the animal auditory system
4.1. Spontaneous firing activity in general
4.2. Effects of salicylate and noise exposure in auditory pathways
4.3. Cell types and afferent pathways
4.4. Hyperacusis
4.5. Neurotransmitters, neuromodulators, and immediate early genes
4.6. Summary
Chapter 5. Evoked potentials and neuroimaging in humans with tinnitus
5.1. Auditory-evoked potentials and tinnitus
5.2. Brain structure, rhythms, and networks
5.3. Brain networks in humans with tinnitus
5.4. Summary
Chapter 6. Tinnitus and hyperacusis: The nonclassical auditory system
6.1. Overview of brain areas activated by sound compared to resting state
6.2. The amygdala
6.3. The hippocampus
6.4. Cingulate cortex
6.5. Human tinnitus and the limbic system
6.6. Comparison of animal and human data
6.7. Cerebellum
6.8. Summary
Chapter 7. Tinnitus and the nonauditory brain
7.1. The nonauditory brain in cognition and perception
7.2. Tinnitus-related changes in structural and functional MRI networks
7.3. EEG/MEG-based network connectivity changes in tinnitus
7.4. Comparing functional connectivity changes in tinnitus and hearing loss
7.5. Connectivity changes of the nucleus accumbens
7.6. Transitions from no-tinnitus to tinnitus, and from acute to chronic tinnitus
7.7. Summary
Chapter 8. Loudness recruitment and hyperacusis: the central-gain model
8.1. Hyperacusis and related symptoms
8.2. Hyperacusis in common disorders
8.3. Loudness recruitment and increased central gain
8.4. Central gain and hyperacusis
8.5. Human studies of hyperacusis
8.6. Mechanisms of hyperacusis
8.7. Summary
Chapter 9. Bottom-up tinnitus models
9.1. The neural synchrony model
9.2. The cortical map reorganization and filling-in models
9.3. The maladaptive plasticity model
9.4. The central gain enhancement model and tinnitus
9.5. The insufficient central compensation model
9.6. Summary
Chapter 10. Top-down tinnitus models
10.1. The Jastreboff model
10.2. The thalamocortical dysrhythmia/global workspace model
10.3. Noise cancellation by frontostriatal gating
10.4. The increased central noise model
10.5. Interacting neural network models
10.6. The sensory predictive coding or Bayesian inference model
10.7. Summary
Chapter 11. Behavioral and pharmaceutical therapy
11.1. Tinnitus retraining therapy and cognitive behavioral therapy
11.2. Sound therapy and/or music therapy
11.3. Cross-modal stimulation
11.4. Effects of pharmaceutical intervention
11.5. Diet and tinnitus
11.6. Summary
Chapter 12. Neurofeedback and neuromodulation: hearing aids, cochlear implants, and transcranial stimulation
12.1. Neurofeedback
12.2. Neuromodulation with hearing aids and cochlear implants
12.3. Noninvasive neuromodulation using transcranial stimulation
12.4. Summary
Index 0aTinnitus. 0aHyperacusis.  a7bcbccorignewd2encipf20gy-gencatlg  2ddccRFT  00102ddc40708R-53/4aAIISHbAIISHd2024-07-10l0o617.8 EGGp23521r2024-07-10 00:00:00w2024-07-10yRFT  00102ddc4070886/3aAIISHbAIISHd2024-07-10l2o617.8 EGG;1p23522r2026-03-27 00:00:00s2026-03-20w2024-07-10ySTS