04156cam a22004575i 450000100090000000300040000900500170001300600190003000700150004900800410006401000170010502000180012202400350014003500320017504000270020707200230023407200170025707200160027408200200029024501030031025000180041326400750043130000620050633600260056833700260059433800360062034700240065650507320068052017160141258800550312865000190318365000250320265000950322765001010332270000320342370000310345577601040348677600360359077600360362677600360366221676008OSt20230221122745.0m    |o  d |      cr |||||||||||180718s2018    gw |||| o    |||| 0|eng    a  2019743930  a97833199250737 a10.1007/978-3-319-92507-32doi  a(DE-He213)978-3-319-92507-3  aDLCbengepnerdacDLC 7aMED0570002bisacsh 7aPSAN2bicssc 7aPSAN2thema04a617.8 RAM R22300aInflammatory Mechanisms in Mediating Hearing Loss /cedited by Vickram Ramkumar, Leonard P. Rybak.  a1st ed. 2018. 1aCham :bSpringer International Publishing :bImprint: Springer,c2018.  aX, 231 pages 39 illustrations, 31 illustrations in color.  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext filebPDF2rda0 aPreface -- The Cochlea -- Oxidative Stress and Hearing Loss -- Corticotropin Releasing Factor Signaling in the Mammalian Cochlea: An Integrative Niche for Cochlear Homeostatic Balance Against Noise -- Cochlear vascular pathology and hearing loss -- Cochlear Inflammation Associated with Noise-Exposure -- Middle Ear Infection and Hearing Loss -- Inflammation potentiates cochlear uptake of ototoxins and drug-induced hearing loss -- The Contribution of Anti-Oxidant and Anti-Inflammatory Functions of Adenosine A1 Receptor In Mediating Otoprotection -- Anti-inflammatory therapies for sensorineural hearing loss -- Implementation and Outcomes of Clinical Trials in Immune-Mediated Hearing Loss and other Rare Diseases -- Index.  aThe primary goal of this project is to describe our current understanding of the oxidant hypothesis of noise and drug-induced hearing loss and show how this process translates into cochlear inflammation. Basic cellular mechanisms underlying the contribution of oxidant stress to hearing loss will be explained and molecular pathways leading to inflammatory processes will be outlined. Several different aspects of the cochlear inflammatory process will be discussed in detail. These include the sources of inflammatory cells, chemokines, inflammatory cytokines and the roles of cochlear resident immune cells in mediating hearing loss. In addition, evidence for a robust cochlear-based steroid axis which is activated by cochlear stress and serves a protective system. The role of the strial vasculature networks which aid in maintenance of the blood-labyrinth barrier and control the entry of circulating immune cells into the cochlea will be described. Molecular pathways leading to activation of the local inflammatory process will be highlighted and otoprotective treatment options will be discussed. The relevance of certain clinically used anti-inflammatory interventions, such as trans-tympanic steroids and other drugs will also be discussed. Furthermore, we will examine recent patents focusing on the use of anti-inflammatory agents for the treatment of drug and noise-induced hearing loss. It is our hope that this book would provide a better understanding of the interaction of oxidative stress and inflammation in hearing loss. This book should provide basic information to scientists in the field of auditory research and to enlighten clinicians who treat patients with potentially ototoxic drugs.  aDescription based on publisher-supplied MARC data. 0aNeurosciences. 0aOtorhinolaryngology.14aNeurosciences.0https://scigraph.springernature.com/ontologies/product-market-codes/B1800624aOtorhinolaryngology.0https://scigraph.springernature.com/ontologies/product-market-codes/H460071 aRamkumar, Vickram.eeditor.1 aRybak, Leonard P.eeditor.08iPrint version:tInflammatory mechanisms in mediating hearing lossz9783319925066w(DLC)  201894819408iPrinted edition:z978303006447108iPrinted edition:z978331992506608iPrinted edition:z9783319925080