02485caa a2200277   4500008004100000022001400041100001600055245013100071260000900202270009100211270010400302270007800406300001400484490002400498520139800522653006901920700001601989700001402005700001802019700002002037700001702057700001702074700002702091773004302118856004602161210629s9999    xx            000 0 und d  a2051-2082  aThakur, A   0a Tranexamic acid has no advantage in head and neck surgical procedures: a randomised, double-blind, controlled clinical trial   c2019  aDepartment of Biostatistics, All India Institute of Speech and Hearing, Mysore, India.  aDepartment of Otolaryngology - Head and Neck Surgery, Indira Gandhi Medical College, Shimla, India.  aDepartment of Pharmacology, Indira Gandhi Medical College, Shimla, India.  a1024-1032  vVolume 133 Issue 12  aObjective: To assess the effect of tranexamic acid in head and neck surgical procedures.Methods: A prospective, double-blind and randomised, parallel group, placebo-controlled clinical trial was conducted. Ninety-two patients undergoing various head and neck surgical procedures were randomised. Subjects received seven infusions of coded drugs (tranexamic acid or normal saline) starting at the time of skin closure. Haematological, biochemical, blood loss and other parameters were observed by the staff, who were blinded to patients' group allocation (case or control).Results: Patients were analysed on the basis of type of surgery. Fifty patients who had undergone surgical procedures, including total thyroidectomy, total parotidectomy, and various neck dissections with or without primary tumour excision, were included in the first group. The second group comprised 41 patients who had undergone hemithyroidectomy, lobectomy or superficial parotidectomy. There was no statistical difference in blood parameters between both groups. There was a reduction in post-operative drain volume, but this was not significant.Conclusion: Although this prospective, randomised, placebo-controlled clinical trial found a reduction in post-operative drain volume in tranexamic acid groups, the difference was not statistically significant between the various head and neck surgical procedure groups.  aControlled Clinical Trial; Head; Neck; Surgery; Tranexamic Acid.  aAzad, R K    aGupta, S   aMinhas, R S    aMohindroo, N K   aSharma, D R   aThakur, J S   aVasanthalakshmi, M S    aThe Journal of Laryngology and Otology  uhttps://doi.org/10.1017/s0022215119002305